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Role of Cyclooxygenase-2 in Pathogenesis and Prevention of Colorectal Cancer

✍ Scribed by Hahn, Ezra; Kraus, Sarah; Arber, Nadir


Book ID
121242648
Publisher
S. Karger AG
Year
2010
Tongue
English
Weight
161 KB
Volume
28
Category
Article
ISSN
0257-2753

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## Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A causal link for COX‐2 in epithelial tumorigenesis was shown in genetically manipulated animal models of colon and bre