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Role of cyclin D1 amplification and expression in vulvar carcinomas

✍ Scribed by Matthias Choschzick; Stephan Hess; Pierre Tennstedt; Frederik Holst; Hiltila Bohlken; Frederike Gieseking; Sven Mahner; Linn Woelber; Ronald Simon; Guido Sauter

Book ID
119257689
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
696 KB
Volume
43
Category
Article
ISSN
1532-8392

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Altered expression of cyclin D1 and CDK4
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We analyzed the expression and amplification of cyclin D1 and CDK4 genes in ovarian carcinomas. Northern blot analysis revealed overexpression of cyclin D1 in 12 of 65 (18%) ovarian carcinomas while CDK4 was overexpressed in 7 of 48 cases (14%). None of the tumors showed amplification of any of the