Amplification and Overexpression of Cyclin D1 in Human Hepatocellular Carcinoma
β Scribed by Y.J. Zhang; W. Jiang; C.J. Chen; C.S. Lee; S.M. Kahn; R.M. Santella; I.B. Weinstein
- Book ID
- 115573723
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 808 KB
- Volume
- 196
- Category
- Article
- ISSN
- 0006-291X
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## Background: Overexpression of cyclin d1 has been documented in a number of human cancers. increased expression of cyclin d1 can contribute to cellular transformation and abnormal proliferation. ## Methods: Quantitative rt-pcr and/or western blot analysis were used to determine the level of cyc
## Abstract The cyclin D1 gene, __CCND1__, located within chromosome 11q13, plays an important role in the regulation of cellβcycle progression and has oncogenic properties. Cyclin D1 frequently is overexpressed in a variety of cancers, including hepatocellular carcinoma (HCC), as a result of gene