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Expression and significance of cyclin D1 in human hepatocellular carcinoma

✍ Scribed by Lian-jun Yang; Xiao-hui Si


Publisher
Chinese Anti-Cancer Association
Year
2001
Tongue
English
Weight
287 KB
Volume
13
Category
Article
ISSN
1000-9604

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## Abstract The cyclin D1 gene, __CCND1__, located within chromosome 11q13, plays an important role in the regulation of cell‐cycle progression and has oncogenic properties. Cyclin D1 frequently is overexpressed in a variety of cancers, including hepatocellular carcinoma (HCC), as a result of gene

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## BACKGROUND. The cyclin D1 gene is amplified and/or overexpressed in several types of human cancer, including cancers of the breast, esophagus, head, and neck. However, the role of cyclin D1 in prostate cancer has not been previously studied in detail. METHODS. Six human prostate cancer cell lin