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Role of CD8 homodimers and heterodimers in the activtion of CD8+ T cells

โœ Scribed by Porto, M.H.O.; DiSanto, J.P.; Terry, L.A.; Chaltry, M.; Flomenberg, N.


Book ID
122444382
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
90 KB
Volume
34
Category
Article
ISSN
0198-8859

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CD4, CD8 and CD45 regulate the coupling of the T-cell receptor complex (CD3-TCR) to tyrosine kinase activation and phosphorylation of key substrates such as phospholipase C gamma 1. CD4 and CD8 contribute to activation signals through their cytoplasmic association with p56lck. Expression of the zeta