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Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

✍ Scribed by Tan, Jun; Town, Terrence; Crawford, Fiona; Mori, Takashi; DelleDonne, Anthony; Crescentini, Robert; Obregon, Demian; Flavell, Richard A.; Mullan, Michael J.

Book ID: 109941313
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 239 KB
Volume: 5
Category: Article
ISSN: 1097-6256
DOI: 10.1038/nn968

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## Abstract The presence of amyloid‐β (Aβ) plaques in the brain is a hallmark pathological feature of Alzheimer's disease (AD). Transgenic mice overexpressing mutant amyloid precursor protein (APP), or both mutant APP and presenilin‐1 (APP/PS1), develop Aβ plaques similar to those in AD patients, a