Role of basolateral membrane conductance in the regulation of transepithelial sodium transport across frog skin
β Scribed by Wolfram Nagel; Uri Katz
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 248 KB
- Volume
- 446
- Category
- Article
- ISSN
- 0031-6768
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Since the pioneer work of du Bois Reymond ( '57), the origin of the potential across the isolated frog skin, a i d the anatomical location of the active site, or sites, has bccn a subject of considera1)le debate arnong physiologists. The predominant, hut by no means unanimous, opinion has bccn that
## NINE FIGURES This paper deals with (1) the production of a hydrogen ion gradient across the isolated frog skin, (2) the relationship between the gradient and the active transport of sodium ion, and (3) the effect of potassium ion and aearation on the hydrogen ion gradient and the transport proc
The effect of papaverine, an inhibitor of the phosphodiesterase responsible for breakdown of cAMP, on the transepithelial sodium transport across the isolated frog skin was investigated. Serosal addition of papaverine caused initially an increase in the short-circuit current (SCC), a doubling of the