The role of the corium in ion transport across the isolated frog skin

✍ Scribed by Fleming, Warren R.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1958
• Tongue: English
• Weight: 515 KB
• Volume: 51
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030510205

✦ Synopsis

Since the pioneer work of du Bois Reymond ( '57), the origin of the potential across the isolated frog skin, a i d the anatomical location of the active site, or sites, has bccn a subject of considera1)le debate arnong physiologists. The predominant, hut by no means unanimous, opinion has bccn that the potential ariscs in the epidermis. As the subject lias been reviewed recently (Ottoscn et al. '53), only a few papers will be cited here.

Since the clear dcnionsti~ition of Ussing ('48) that the isolated frcg skin is ahlc to transport sodium ion actively, and his proposal that the potential arises as a result of the active transport ( Ussing 'if?, 49, Ussing arid Zerahn 'Sl), the search for the active site gained nem7 impetus. IJssing suggested that the active site probably lay in thc basal cell layer of the strcrtum prniincnti?iuin. I n Ussing's view, the corium, being largely muscle fibws and connective tissut, is too diffuse a structuw to act as a barrier to diffusion (TJssing '48).