Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation

✍ Scribed by Pratima Gupta; Anand Kar

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 130 KB
• Volume: 18
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(1998090)18:5<317::aid-jat514>3.0.co;2-u

✦ Synopsis

A study on the effects of ascorbic acid (AA) on heavy metal (cadmium)-induced thyroid dysfunction and lipid peroxidation (LPO) was carried out in Swiss male mice. The animals were administered with either cadmium (1.0 mg kg -1 body wt.) alone or in combination with AA (1 mM) every day for 15 days. While cadmium treatment led to a decrease in the serum concentrations of thyroid hormones and hepatic type I iodothyronine 5Ј-monodeiodinase (5ЈD-I) activity, an increase in the level of lipid peroxidation was observed. The metal-induced decrease in hepatic 5ЈD-I activity and serum triiodothyronine (T 3 ) concentration was restored by treatment with AA. However, AA could not restore the serum thyroxine (T 4 ) concentration. The increased level of LPO was also ameliorated by AA. It appears that the protective effect of AA against cadmium-induced thyroid dysfunction is mediated through its antioxidative action.