Dual Role of Testosterone in Fenvalerate-treated Mice with Respect to Thyroid Function and Lipid Peroxidation
✍ Scribed by Prasanta Kumar Maiti; Anand Kar
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 172 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Effects of testosterone propionate (TP, 2.5 mg kg -1 body weight) in fenvalerate-induced (120 mg kg -1 body weight) thyroid dysfunction and lipid peroxidation were investigated in male mice. Testosterone propionate aggravated in the inhibition of hepatic type I iodothyronine 5′-monodeiodinase (5′D-I) activity, coupled with a decrease in serum triiodothyronine (T 3 ) concentration in pesticide-treated mice. However, it could ameliorate the toxicity as indicated by decreased hepatic lipid peroxidation (LPO) with a marginal but significant increase in superoxide dismutase and catalase activities following fenvalerate treatment. While protective effects of testosterone on LPO indicated its antiperoxidative property, the decrease in 5′D-I activity could be because of the increased accumulation of fenvalerate in the tissues following TP administration.