Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation?

✍ Scribed by Prasanta Kumar Maiti; Anand Kar

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 107 KB
• Volume: 18
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199803/04)18:2<125::aid-jat483>3.0.co;2-r

✦ Synopsis

A study on the effect of triiodothyronine (T 3 ) in the regulation of pyrethroid (fenvalerate)-induced thyroid dysfunction and lipid peroxidation was carried out in male mice. Fenvalerate (120 mg kg ؊1 body wt. daily for 15 days) administration led to a decrease in the serum concentration of thyroid hormones and the activity of hepatic type I iodothyronine 5Ј-monodeiodinase (5ЈD-I) and an increase in the level of lipid peroxidation. The decrease in the activity of hepatic 5ЈD-I due to the administration of fenvalerate was restored with the administration of T 3 (7 g kg ؊1 body wt. on alternate days). The increased level of lipid peroxidation was also ameliorated by T 3 . However, T 3 could not restore the serum concentration of thyroxine (T 4 ), only that of T 3 . We suggest that the ameliorating role of T 3 in the fenvalerate-intoxicated mice could be the result of the lipogenic action of the thyroid hormone, which in turn led to the restoration of 5ЈD-I activity.