Robust Tests for Single-marker Analysis in Case-Control Genetic Association Studies
β Scribed by Qizhai Li; Gang Zheng; Xueying Liang; Kai Yu
- Book ID
- 111111485
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 313 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0003-4800
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The trend test under the additive model is commonly used when a case-control genetic association study is carried out. However, for many complex diseases, the underlying genetic models are unknown and a mis-specification of the genetic model may result in a substantial loss of power. MAX3 has been p
## Abstract In caseβcontrol single nucleotide polymorphism (SNP) data, the allele frequency, Hardy Weinberg Disequilibrium, and linkage disequilibrium (LD) contrast tests are three distinct sources of information about genetic association. While all three tests are typically developed in a retrospe
## Abstract For a dense set of genetic markers such as single nucleotide polymorphisms (SNPs) on high linkage disequilibrium within a small candidate region, a haplotypeβbased approach for testing association between a disease phenotype and the set of markers is attractive in reducing the data comp