Marker selection for genetic case–control association studies
✍ Scribed by Pettersson, Fredrik H; Anderson, Carl A; Clarke, Geraldine M; Barrett, Jeffrey C; Cardon, Lon R; Morris, Andrew P; Zondervan, Krina T
- Book ID
- 109946749
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 603 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1750-2799
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## Abstract In case‐control studies of unrelated subjects, gene‐based hypothesis tests consider whether any tested feature in a candidate gene—single nucleotide polymorphisms (SNPs), haplotypes, or both—are associated with disease. Standard statistical tests are available that control the false‐pos
## Abstract For a dense set of genetic markers such as single nucleotide polymorphisms (SNPs) on high linkage disequilibrium within a small candidate region, a haplotype‐based approach for testing association between a disease phenotype and the set of markers is attractive in reducing the data comp