Robust Estimation for Secondary Trait Association in Case-Control Genetic Studies
โ Scribed by Tapsoba, J. d. D.; Kooperberg, C.; Reiner, A.; Wang, C.-Y.; Dai, J. Y.
- Book ID
- 121834324
- Publisher
- Oxford University Press
- Year
- 2014
- Tongue
- English
- Weight
- 192 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0002-9262
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The trend test under the additive model is commonly used when a case-control genetic association study is carried out. However, for many complex diseases, the underlying genetic models are unknown and a mis-specification of the genetic model may result in a substantial loss of power. MAX3 has been p
## Abstract Populationโbased caseโcontrol design has become one of the most popular approaches for conducting genomeโwide association scans for rare diseases like cancer. In this article, we propose a novel method for improving the power of the widely used singleโsingleโnucleotide polymorphism (SNP