Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia
โ Scribed by Jack Spira; Francis Wiener; George Klein
- Book ID
- 119102683
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 683 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Four combinations of translocation heterozygotes with cytogenetically distinct chromosomes 15 were used to investigate whether the Tโcell leukemiaโassociated duplication of chromosome 15 is a nonโrandom or a random event. In leukemias of AKR X CBAT6T6 F~1~ (Group I) and C57BL X CBAT6T6
Trisomy 15 is the most common chromosomal aberration in murine T-cell lymphomas. The relevant chromosomal region responsible for the growth advantage of the 15-trisomic cell has not been defined. In order to map this region, we have induced thymic lymphomas by chemical carcinogens (DMBA or MNU) in m
Two translocationcarrying stocks of mice, T(7; I5)9H and Rb(4;lS) were resistant to chemical leukemogenesis by 7,1Z-dimethylbenz(a)-anthracene (DMBA) or methylnitroso-Nurea (MNU). Lymphomas were induced in F, hybrids derived from crossing these two stocks with various susceptible strains. In T-cell
## Abstract Trisomy of chromosome 15 is a highly regular feature of murine Tโcell leukemogenesis. We have studied the chromosomal constitution of 7,12โdimethylbenz(__a__)anthracene (DMBA)โinduced Tโcell leukemias in C57BL ร CBAT6T6 F, mice. The CBAT6T6โderived chromosome 1(14:15)6 was regularly dup
Provirus insertion near the c-myc, p i m l or Mlvi-l genes occurred in 7 out of 59 virally induced T-cell leukemias. C-myc was exclusively rearranged in approximately 10% of MCF247-induced tumors while Mlvi-l was rearranged to a similar frequency in Moloney-virus-induced lymphomas. Out of 25 karyoty