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Non-random duplication of chromosome 15 in T-cell leukemias induced in mice heterozygous for reciprocal and robertsonian translocations

✍ Scribed by Francis Wiener; Jack Spira; Magda Babonits; George Klein

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
783 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Two translocationcarrying stocks of mice, T(7; I5)9H and Rb(4;lS) were resistant to chemical leukemogenesis by 7,1Z-dimethylbenz(a)-anthracene (DMBA) or methylnitroso-Nurea (MNU). Lymphomas were induced in F, hybrids derived from crossing these two stocks with various susceptible strains. In T-cell leukemias originating from F, hybrids with Rb(4;lS) as one parent and strain CBA or ASW as the other, the translocation chromosome

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Non-random duplication of chromosome 15
Non-random duplication of chromosome 15 in murine T-cell leukemias induced in mice heterozygous for translocation 1(14:15)6
✍ Francis Wiener; Jack Spira; Shinsuke Ohno; Nechama Haran-Ghera; George Klein 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 289 KB

## Abstract Trisomy of chromosome 15 is a highly regular feature of murine T‐cell leukemogenesis. We have studied the chromosomal constitution of 7,12‐dimethylbenz(__a__)anthracene (DMBA)‐induced T‐cell leukemias in C57BL × CBAT6T6 F, mice. The CBAT6T6‐derived chromosome 1(14:15)6 was regularly dup

Non-random duplication of chromosome 15
Non-random duplication of chromosome 15 in murine T-cell leukemias: Further studies on translocation heterozygotes
✍ F. Wiener; J. Spira; M. Babonits; N. Haran-Ghera; G. Klein 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 598 KB

## Abstract Four combinations of translocation heterozygotes with cytogenetically distinct chromosomes 15 were used to investigate whether the T‐cell leukemia‐associated duplication of chromosome 15 is a non‐random or a random event. In leukemias of AKR X CBAT6T6 F~1~ (Group I) and C57BL X CBAT6T6