Further studies on chromosome 15 trisomy in murine T-cell lymphomas: Mapping of the relevant chromosome segment

✍ Scribed by Santiago Silva; Magda Babonits; Francis Wiener; George Klein

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: French
• Weight: 679 KB
• Volume: 41
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910410517

✦ Synopsis

Trisomy 15 is the most common chromosomal aberration in murine T-cell lymphomas. The relevant chromosomal region responsible for the growth advantage of the 15-trisomic cell has not been defined. In order to map this region, we have induced thymic lymphomas by chemical carcinogens (DMBA or MNU) in mice with 2 different constitutional translocations, T(7; 15)OH homozygotes and [T(7; I5)PH x T(5; 15)4Ad] F, hybrids. Twenty-two tumors developed in 90 carcinogen-treated mice. Among the 14 cytogenetically analyzed thymic lymphomas, 4 were diploid and 5 were aneuploid, with no chromosome-IS-associated chahges. Five lymphomas showed partial duplication of chromosome 15. Four of them have duplicated the segment distal to the C/DI breakpoint of TPH, while the 5th carried an interstitial duplication of the D2 sub-band of the T(7;IS) translocation chromosome. These findings suggest that the duplication of the D 2/3 region, known to contaln the c-myc and the pvt-l genes (Banerjee et a/., 1985). rather than other regions of chromosome 15, contributes to the development andlor progression of murine T-cell leukemias.