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Rituximab and alemtuzumab induce a nonclassic, caspase-independent apoptotic pathway in B-lymphoid cell lines and in chronic lymphocytic leukemia cells

✍ Scribed by Michael Stanglmaier; Simone Reis; Michael Hallek

Book ID: 105988474
Publisher: Springer
Year: 2004
Tongue: English
Weight: 433 KB
Volume: 83
Category: Article
ISSN: 0939-5555
DOI: 10.1007/s00277-004-0917-0

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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF