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Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism

✍ Scribed by Mone, A P; Cheney, C; Banks, A L; Tridandapani, S; Mehter, N; Guster, S; Lin, T; Eisenbeis, C F; Young, D C; Byrd, J C

Book ID: 110056535
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 179 KB
Volume: 20
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2404014

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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF