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Risk factors for dopaminergic neuron loss in human α-synuclein transgenic mice

✍ Scribed by M. J. Thiruchelvam; J. M. Powers; D. A. Cory-Slechta; E. K. Richfield

Book ID
110756434
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
410 KB
Volume
19
Category
Article
ISSN
0953-816X

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## Abstract Parkinson's disease is neuropathologically characterized by the presence of Lewy bodies, whose major component is α‐synuclein. We had previously generated transgenic mice that expressed human α‐synuclein carrying an Ala53Thr point mutation (hα‐syn140m) under the control of the rat tyros