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Ring size effect in the PKC inhibitory activities of perhydroazepine analogs of balanol

✍ Scribed by Yen-Shi Lai; David S. Menaldino; Jeffrey B. Nichols; G. Erik Jagdmann Jr.; Frankie Mylott; Jan Gillespie; Steven E. Hall

Book ID: 103983076
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 185 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00365-z

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Balanol ((-)-!) is a potent protein kinase inhibitory natural product isolated from the fungus Vertici/lium ba/anoides. The presence of an ester functionality in this molecule has prompted concern over the metabolic stability of balanol, and has led to a search for active analogs lacking this moiety