Ring opening of cyclopropyl ketones by trimethylsilyl iodide
โ Scribed by Miller, Robert D.; McKean, Dennis R.
- Book ID
- 120284302
- Publisher
- American Chemical Society
- Year
- 1981
- Tongue
- English
- Weight
- 429 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Functionalized cyclopropyl ketones have been found to undergo facile reductive cyclopropane ring opening with samarium (II) diiodide in the presence of a proton source. These reactions were exceedingly rapid, taking place in most cases at -78ยฐC under neutral conditions. An ester group substitut
The powerful electrophile trimethylsilyl iodide in the presence of certain catalysts rapidly and cleanly initiates the ring opening of a variety of cyclobutanone derivatives in a highly regioselective fashion yielding ultimately B-iodoketones. The synthetic accessibility and high reactivity of cycl