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Ring opening of cyclopropyl ketones by trimethylsilyl iodide

โœ Scribed by Miller, Robert D.; McKean, Dennis R.


Book ID
120284302
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
429 KB
Volume
46
Category
Article
ISSN
0022-3263

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The powerful electrophile trimethylsilyl iodide in the presence of certain catalysts rapidly and cleanly initiates the ring opening of a variety of cyclobutanone derivatives in a highly regioselective fashion yielding ultimately B-iodoketones. The synthetic accessibility and high reactivity of cycl