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Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras gene

โœ Scribed by Makoto Koizumi; Hiroyuki Kamiya; Eiko Ohtsuka

Book ID
118047941
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
516 KB
Volume
117
Category
Article
ISSN
0378-1119

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โœ Tatsuo Ohira; Kazuto Nishio; Fumihiko Kanzawa; Tomoyuki Ishida; Yuichiro Ohe; Hi ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 736 KB

We examined the effects of the introduction of H-ras oncogene into murine cell line NIH3T3 on growth inhibition by topoisomerase-I (topo-I) inhibitors. The H-ras-transformed cells (pT22-3) showed approximately I 2-fold increased sensitivity to a novel topo-l inhibitor, NB-506 [6-N-formylamino-I2,I3d