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Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes

✍ Scribed by Alexander Levitzki; Joyce Rudick; Ira Pastan; William C. Vass; Douglas R. Lowy

Book ID: 115917938
Publisher: Elsevier Science
Year: 1986
Tongue: English
Weight: 562 KB
Volume: 197
Category: Article
ISSN: 0014-5793
DOI: 10.1016/0014-5793(86)80313-1

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## Abstract Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras‐mediated transformation. We identified a novel potent inhibitor of Ras‐mediated morphologi