๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

RIBOSOME SYNTHESIS IN TETRAHYMENA: A QUANTITATIVE ANALYSIS

โœ Scribed by Leif K Larsen; Per H Andreasen; Karsten Kristiansen

Book ID
102567583
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
480 KB
Volume
23
Category
Article
ISSN
1065-6995

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โœฆ Synopsis

Abstract

We have performed a detailed quantitative analysis of the transcription and accumulation of ribosomal RNA and ribosomal protein mRNA in the ciliated protozoan Tetrahymena thermophila during changes in growth conditions, and found that: (1) nutritional downshifts lead to a rapid decrease in transcriptional activity whereas nutritional upshifts lead to rapid restoration of transcriptional activity, (2) starvation leads to decreased translation of ribosomal protein mRNA and (3) the rate of ribosomal protein mRNA degradation decreases after a nutritional upshift. We present evidence that the proximal promoters of two ribosomal protein genes and the ribosomal RNA gene compete for binding of nuclear factor(s) in vitro, suggesting that the coordinated regulation of these genes may involve a common set of transcriptional regulators.

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## Abstract Three parameters involved in the production of new ribosomal RNA (rRNA) were measured in __Tetrahymena thermophilia:__ (i) the rate of synthesis of the rRNA precursor, (ii) the rate of processing of the RNA precursor and rRNA intermediates and (iii) the efficiency of utilization of the