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Quantitative Proteomic Analysis of Ribosome Assembly and Turnover In Vivo

โœ Scribed by Michael T. Sykes; Zahra Shajani; Edit Sperling; Andrea H. Beck; James R. Williamson

Book ID
116664459
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
291 KB
Volume
403
Category
Article
ISSN
0022-2836

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We have measured the synthesis and stability of ribosomal proteins in a temperature sensitive strain of yeast which at the restrictive temperature is specifically blocked in the processing of 27S ribosomal precursor RNA. We find that in the absence of 60S ribosomal subunit assembly, the synthesis of