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Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway

✍ Scribed by Shigang Lin; Makoto Fujii; De-Xing Hou


Book ID
116176771
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
461 KB
Volume
418
Category
Article
ISSN
0003-9861

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Peroxyacetyl nitrate (PAN), an ubiquitous air pollutant, induced apoptosis in human leukemia HL-60, human chronic myelogenous leukemia K-562, and mouse monocyte-macrophage RAW 264.7 cell lines. In the HL 60 cells, characteristic apoptosis morphology could be observed 4 h after the cells were treated