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Rhadinovirus vector-derived human telomerase reverse transcriptase expression in primary T cells

✍ Scribed by Toptan, T; Ensser, A; Fickenscher, H


Book ID
109855433
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
503 KB
Volume
17
Category
Article
ISSN
0969-7128

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Human telomerase reverse transcriptase, hTERT, has been identified as the catalytic enzyme required for telomere elongation. hTERT is expressed in most tumor cells but seldom expressed in most human adult cells. It has been reported that 80% to 90% of hepatocellular carcinomas (HCCs) express hTERT,