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Tamoxifen regulates human telomerase reverse transcriptase (hTERT) gene expression differently in breast and endometrial cancer cells

โœ Scribed by Wang, Zhuo; Kyo, Satoru; Maida, Yoshiko; Takakura, Masahiro; Tanaka, Masaaki; Yatabe, Noriyuki; Kanaya, Taro; Nakamura, Mitsuhiro; Koike, Koji; Hisamoto, Koji


Book ID
110066657
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
244 KB
Volume
21
Category
Article
ISSN
0950-9232

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Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements an