Direct serum injection methods are described for the HPLC determination of selected non-steroidal anti-inflammatory drugs (NSAIDS) on restricted access media (RAM) columns, using either a Pinkerton (ISRP) or semi-permeable surface (SPS) column. Twenty microlitres of a filtered serum sample was injec
Review of Drug Analysis with Direct Serum Injection on the HPLC Column
β Scribed by Shihabi, Z. K.
- Book ID
- 120054446
- Publisher
- Informa UK (Taylor & Francis)
- Year
- 1988
- Tongue
- English
- Weight
- 515 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0148-3919
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## Abstract A simple and quick gas chromatographic method has been developed for the determination of up to six commonly used antiepileptic drugs in human serum. The antiepileptics are isolated from serum by solid phase extraction on to a reversed phase sorbent and recovered with ethyl acetate as e
A semipermeable surface (SPS) HPLC column has been used to develop a direct injection method for the simultaneous determination of chlorzoxazone and its 6-hydroxy metabolite in serum. Spiked serum was filtered and 20 L injected directly onto the SPS column. The separation was achieved within 25 min