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Reversion of the multiple-drug resistance phenotype mediated by short interfering RNAs

✍ Scribed by E. B. Logashenko; A. V. Vladimirova; A. N. Zenkov; M. N. Repkova; A. G. Ven'yaminova; E. L. Chernolovskaya; V. V. Vlassov

Book ID
106519743
Publisher
Springer
Year
2005
Tongue
English
Weight
365 KB
Volume
54
Category
Article
ISSN
1573-9171

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## Abstract Breast cancer resistance protein (BCRP) is an ATP‐binding cassette multidrug transporter that confers resistance to various anticancer drugs like Mitoxantrone. Overexpression of BCRP confers multidrug resistance (MDR) in cancer cells and is a frequent impediment to successful chemothera