๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

mdr1 Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines

โœ Scribed by Carmel Daly; Seamus Coyle; Shirley McBride; Lorraine O'Driscoll; Noel Daly; Kevin Scanlon; Martin Clynes


Publisher
Springer
Year
1996
Tongue
English
Weight
766 KB
Volume
19
Category
Article
ISSN
0920-9069

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Lentivirus-mediated RNA interference rev
โœ Xueshi Ye; Ting Liu; Yuping Gong; Bohui Zheng; Wentong Meng; Yamei Leng ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 464 KB

Multidrug-resistance (MDR) is a major hindrance to successful chemotherapy. The emergence of MDR is multi-factorial. Among them, the MDR1 gene/P-glycoprotein (P-gp) is a popular and important reason. In our study, an MDR1 single-factorial drug-resistant leukemia cell line K562/MDR1 was constructed v

Upregulation of bcl-2 is involved in the
โœ Ute A. Sartorius; Peter H. Krammer ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 325 KB

## Abstract Chemotherapeutic drugs eliminate cancer cells by induction of apoptosis. Resistance to chemotherapy is partly due to a decreased apoptosis rate. Here we investigated resistance to anticancer drugs in 9 small cell lung cancer (SCLC) cell lines. Apoptosis was induced by cisplatin, doxorub

Cytogenetic and molecular characterizati
โœ Turid Knutsen; Lyn A. Mickley; Thomas Ried; Eric D. Green; Stanislas du Manoir; ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 835 KB

Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at