Multidrug-resistance (MDR) is a major hindrance to successful chemotherapy. The emergence of MDR is multi-factorial. Among them, the MDR1 gene/P-glycoprotein (P-gp) is a popular and important reason. In our study, an MDR1 single-factorial drug-resistant leukemia cell line K562/MDR1 was constructed v
mdr1 Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines
โ Scribed by Carmel Daly; Seamus Coyle; Shirley McBride; Lorraine O'Driscoll; Noel Daly; Kevin Scanlon; Martin Clynes
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 766 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0920-9069
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## Abstract Chemotherapeutic drugs eliminate cancer cells by induction of apoptosis. Resistance to chemotherapy is partly due to a decreased apoptosis rate. Here we investigated resistance to anticancer drugs in 9 small cell lung cancer (SCLC) cell lines. Apoptosis was induced by cisplatin, doxorub
Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at