A 56-year-old man developed procainamide-induced agranulocytosis. Bone marrow aspiration showed the absence of myeloid elements beyond the promyelocyte stage. Procainamide at therapeutic concentrations in vitro depressed bone marrow granulocyte-macrophage colonies (CFUc) while CFUc growth was normal
β¦ LIBER β¦
REVERSIBLE PROCAINAMIDE-INDUCED AGRANULOCYTOSIS TWICE IN ONE PATIENT
β Scribed by Konttinen, Y.P.; Tuominen, L.
- Book ID
- 122987119
- Publisher
- The Lancet
- Year
- 1971
- Tongue
- English
- Weight
- 166 KB
- Volume
- 298
- Category
- Article
- ISSN
- 0140-6736
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All available asymptomatic patients (those who had no manifestations suggestive of drug-induced lupus ) receiving procainamide or quinidine were included in the study. A series of 90 controls taking neither drug was also studied. Those with inflammatory and connective tissue diseases were excluded.