Procainamide-induced serologic changes in asymptomatic patients

✍ Scribed by Javier Molina; Dr. Edmund L. Dubois; Michael Bilitch; Stephen L. Bland; George J. Friou

• Book ID: 102749873
• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 515 KB
• Volume: 12
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780120608

✦ Synopsis

All available asymptomatic patients (those who had no manifestations suggestive of drug-induced lupus ) receiving procainamide or quinidine were included in the study. A series of 90 controls taking neither drug was also studied. Those with inflammatory and connective tissue diseases were excluded. The patients were otherwise selected as randomly as possible from among hospitalized medical patients until an appropriate number were obtained in each sex and decade. The majority suffered from degenerative cardiovascular disease. The following tests were done: rotary and rotarywashed clot LE cell preparations in the drugtreated groups,l7 immunofluorescent tests for ANA using as substrates calf thymus nucleoprotein and calf thymus DNA spots,ls total complement,lU and rheumatoid factor.