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Reversible inhibition by human serum lipoproteins of cell proliferation

โœ Scribed by Fumiaki Ito; Yuko Takii; Jiro Suzuki; Yukito Masamune

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
747 KB
Volume
113
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

Abstract

Normal human serum or plasma was studied for the presence of inhibitors of cell proliferation by assaying inhibition of incorporation of labeled thymidine into acidโ€insoluble fraction using human FL cells. Lipoprotein fraction obtained by gel filtration through Sepharose 4B and by KBr density gradient centrifugation was found to play a major part of the inhibitory activity of the serum. It was also shown that the inhibitory activity resides in lowโ€density lipoprotein (LDL). The addition of the lipoprotein fraction to growing FL cells caused an early decrease in the transport of uridine and thymidine across the membrane. This change in the permeability of membrane was followed by the preferential inhibition of DNA synthesis and a reduction in the percentage of mitotic cells in the cell population. The inhibition of the growth was reversible and was observed in various types of cells irrespective of species.

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