Lazaroids inhibit proliferation of cultured human astrocytoma cells

✍ Scribed by Poonam Arora; Yong Soo Lee; Thomas C. Origitano; Robert D. Wurster

• Publisher: Springer US
• Year: 1996
• Tongue: English
• Weight: 465 KB
• Volume: 29
• Category: Article
• ISSN: 0167-594X
• DOI: 10.1007/bf00182137

✦ Synopsis

Lazaroids (or 21-aminosteroids) are potent lipid peroxidation inhibitors and are more potent antioxidants than steroids which have been shown to suppress tumor proliferation. The effects of two lazaroid compounds (U-75389G and U-83836E) were tested on the proliferation of a human brain astrocytoma cell line U-373 MG. Both lazaroids had dose-dependent growth-inhibitory effects on the proliferation of U-373 MG. For purposes of comparison, two steroids (methylprednisolone and dexamethasone) and a highly potent antioxidant (alpha-tocopherol) were tested under similar experimental conditions and were found to have antiproliferative effects as well, although at higher dose ranges. As cell growth-inhibitors, lazaroids are more effective than alpha-tocopherol while they are advantageous over glucocorticoids for their actions are devoid of the usual glucocorticoid side-effects.