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Reverse engineering of the giant muscle protein titin

โœ Scribed by Li, Hongbin; Linke, Wolfgang A.; Oberhauser, Andres F.; Carrion-Vazquez, Mariano; Kerkvliet, Jason G.; Lu, Hui; Marszalek, Piotr E.; Fernandez, Julio M.


Book ID
109890427
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
457 KB
Volume
418
Category
Article
ISSN
0028-0836

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The evolution of titin and related giant
โœ Desmond G. Higgins; Siegfried Labeit; Mathias Gautel; Toby J. Gibson ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Springer ๐ŸŒ English โš– 914 KB

Titin and twitchin are giant proteins expressed in muscle. They are mainly composed of domains belonging to the fibronectin class III and immunoglobulin c2 families, repeated many times. In addition, both proteins have a protein kinase domain near the C-terminus. This paper explores the evolution of