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Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk

โœ Scribed by Zou, Peijian; Pinotsis, Nikos; Lange, Stephan; Song, Young-Hwa; Popov, Alexander; Mavridis, Irene; Mayans, Olga M.; Gautel, Mathias; Wilmanns, Matthias

Book ID
109895478
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
385 KB
Volume
439
Category
Article
ISSN
0028-0836

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Titin and twitchin are giant proteins expressed in muscle. They are mainly composed of domains belonging to the fibronectin class III and immunoglobulin c2 families, repeated many times. In addition, both proteins have a protein kinase domain near the C-terminus. This paper explores the evolution of