Retrovirus mediated gene transfer into hemopoietic cells
✍ Scribed by Melchner, H. ;H�ffken, K.
- Publisher
- Springer-Verlag
- Year
- 1988
- Weight
- 496 KB
- Volume
- 57
- Category
- Article
- ISSN
- 1432-0584
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## Abstract ## Background Retrovirus‐mediated gene transfer is a useful technology in studying the biology of hematopoietic stem cells (HSCs) as well as in developing gene therapy products for a variety of human diseases. One of the most important factors determining the success of these studies i
## Abstract A quantitative understanding of the process of retrovirus‐mediated gene transfer into mammalian cells should assist the design and optimization of transduction protocols. We present a mathematical model of the process that incorporates the essential rate‐limiting transduction steps incl
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