Retroviral transduction of T-cell antigen receptor β-chain and myc genes
✍ Scribed by Fulton, Ruth; Forrest, Douglas; McFarlane, Robert; Onions, David; Neil, James C.
- Book ID
- 109748691
- Publisher
- Nature Publishing Group
- Year
- 1987
- Tongue
- English
- Weight
- 644 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/326190a0
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The nucleotide sequences of 38 T-cell receptor (Tcr) beta-chain cDNA clones which were isolated from a cDNA library (2 x 10(6) plaques) constructed from bovine peripheral blood lymphocytes were determined. Of 38 cDNA clones, 22 were rearranged and contained the functional variable (V) gene segments.
## Abstract We studied rearrangement of human T cell receptor genes (TCR) of Cβ, Cγ, Vγ and Jγ in 34 cases of adult T cell leukemia/lymphoma (ATLL), consisting of 29 cases with monoclonally integrated HTLV‐I proviral DNA (ATLL‐W) and five without monoclonal integration (ATLL‐O), in comparison with