## Abstract Expression of Tβcellβreceptor (TCR) VΞ± and VΞ² genes in tumorβinfiltrating lymphocytes (TILs) of 29 patients, 15 melanomas and 14 malignant glial tumors (glioma and medulloblastoma), was investigated. The identification and propagation of T cells with antiβtumor reactivity is crucial to
Enhancement of T Cell Receptor Signaling of Tumor-infiltrating Lymphocytes by Retrovirally Mediated fyn Gene Transduction
β Scribed by Fujita, Kazuyuki ;Ikarashi, Hirokazu ;Takakuwa, Koichi ;Kodama, Shoji ;Akagi, Tsuyoshi ;Yamamoto, Tadashi ;Tanaka, Kenichi
- Book ID
- 108580904
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1994
- Tongue
- English
- Weight
- 399 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0910-5050
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure o
Tumor-infiltrating lymphocytes (TlL) freshly obtained from human malignant melanomas as well as the same TIL grown in the presence of interleukin 2 (IL2) were studied for gene expression of the T-cell receptor (TCR) variable P regions (VP). To perform the TCR-VP analysis, total RNA was isolated fro
Genetic engineering of human T lymphocytes to express tumor antigen-specific chimeric immune receptors is an attractive means for providing large numbers of effector cells for adoptive immunotherapy while bypassing major mechanisms of tumor escape from immune recognition. We have applied this strate