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Direct transfer of a foreign MHC gene into human melanoma alters T cell receptor Vβ usage by tumor-infiltrating lymphocytes

✍ Scribed by Lisa A. DeBruyne; Alfred E. Chang; Mark J. Cameron; Zhi-yong Yang; David Gordon; Elizabeth G. Nabel; Gary J. Nabel; D. Keith Bishop


Publisher
Springer-Verlag
Year
1996
Tongue
English
Weight
487 KB
Volume
43
Category
Article
ISSN
0340-7004

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Usage of T-cell receptor Vβ chain genes
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Tumor-infiltrating lymphocytes (TlL) freshly obtained from human malignant melanomas as well as the same TIL grown in the presence of interleukin 2 (IL2) were studied for gene expression of the T-cell receptor (TCR) variable P regions (VP). To perform the TCR-VP analysis, total RNA was isolated fro