Enzymatic synthesis of (6R)- and (6S)-fl
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Peter J. Duggan; Emily Parker; John Coggins; Chris Abell
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Article
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1995
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Elsevier Science
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English
โ 321 KB
6-Fluoroshikimates have interesting antibiotic properties. The enzymatic preparation of (6R)-and (6S)-fluoroshikimates from 3-fluorophosphoenolpyruvate is described. The multistep enzymatic conversion is followed by UV and 19F NMR spectroscopy. The shikimic acid pathway is an established target for