A one-pot synthesis of 6-deoxy-6-[18F]fluoro-L-ascorbic acid (18F-DFA) has been developed via nucleophilic displacement of a cyclic sulfate with no-carrier-added [18F]fluoride ion. Isolated radiochemical yields of around 15% were obtained with radiochemical purity of over 99% after overall synthesis
Synthesis of 6-deoxy-6-fluoro-L-ascorbic acid
✍ Scribed by J. Kiss; W. Arnold
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 153 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1420-682X
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