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RETpolymorphisms and sporadic medullary thyroid carcinoma in a portuguese population

✍ Scribed by Patrícia Costa; Rita Domingues; Luís G. Sobrinho; Maria João Bugalho

Book ID
111638125
Publisher
Springer
Year
2005
Tongue
English
Weight
135 KB
Volume
27
Category
Article
ISSN
0969-711X

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✍ Charis Eng; Lois M. Mulligan; Darrin P. Smith; Catherine S. Healey; Andrea Frill 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 375 KB

Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I