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Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression

✍ Scribed by Peter S Burrage, Adam C Schmucker, Yanqing Ren…


Book ID
120706750
Publisher
BioMed Central
Year
2008
Tongue
English
Weight
899 KB
Volume
10
Category
Article
ISSN
1478-6354

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## Abstract The peroxisome proliferator‐activated receptor‐α (PPAR‐α) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR‐α agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE