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Peroxisome proliferator-activated receptor-α and retinoid X receptor agonists inhibit inflammatory responses of astrocytes

✍ Scribed by Jihong Xu; Janet A. Chavis; Michael K. Racke; Paul D. Drew

Book ID
113729857
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
195 KB
Volume
176
Category
Article
ISSN
0165-5728

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Agonists for the peroxisome proliferator
Agonists for the peroxisome proliferator-activated receptor-α and the retinoid X receptor inhibit inflammatory responses of microglia
✍ Jihong Xu; Paul D. Storer; Janet A. Chavis; Michael K. Racke; Paul D. Drew 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 348 KB

## Abstract The peroxisome proliferator‐activated receptor‐α (PPAR‐α) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR‐α agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE