## Abstract The peroxisome proliferator‐activated receptor‐α (PPAR‐α) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR‐α agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE
✦ LIBER ✦
Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: Implications for multiple sclerosis
✍ Scribed by Paul D. Storer; Jihong Xu; Janet Chavis; Paul D. Drew
- Book ID
- 113729518
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 203 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0165-5728
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## Abstract We evaluated RS5444, a thiazolidinedione high affinity PPARγ agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)‐treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last inj