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Response of myasthenia gravis to rituximab in a patient with non-Hodgkin lymphoma

✍ Scribed by Ajeet Gajra; Neerja Vajpayee; Sara J. Grethlein

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
43 KB
Volume
77
Category
Article
ISSN
0361-8609

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✦ Synopsis

Abstract

Myasthenia gravis is a B‐cell‐mediated autoimmune neuromuscular disorder characterized by weakness and fatigability of skeletal muscles. The underlying defect is an autoantibody‐mediated attack on the acetylcholine receptors (AchRs) at the neuromuscular junction. Rituximab is a genetically engineered chimeric murine/human monoclonal antibody indicated for treatment of patients with low‐grade or follicular, CD20‐positive, B‐cell non‐Hodgkin lymphoma. Based on its potential for elimination of auto‐reactive B‐cell clones, rituximab may have a role in the management of some autoimmune disorders. We report a patient with B‐cell, follicular non‐Hodgkin lymphoma and a long‐standing history of myasthenia gravis and the favorable impact of rituximab on both disorders. Am. J. Hematol. 77:196–197, 2004. © 2004 Wiley‐Liss, Inc.

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