β Scribed by Bruce C. Gibb
No coin nor oath required. For personal study only.
Metal ions are superb at templating the synthesis of small macrocycles that are decorated with Lewis basic sites. However, for the synthesis of larger macrocycles, or the synthesis of macrocycles devoid of an array of Lewis basic sites, metal ions are less useful. Here we demonstrate that resorcinarenes can be used as templates to engender the efficient formation of large crown ethers. A three step process of 1) tethering moieties to the template, 2) linking those moieties, and 3) then cleaving off the template leads to the efficient formation of a family of aromatic crown ethers. If adaptable, this approach will prove useful for the construction of macrocycles that are hard to obtain from a stepβwise synthesis.
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This special thematic issue of Peptide Science is guest edited by Claudio Toniolo and Scott Miller. The papers collected by Toniolo and Miller illustrate the natural bridging role that peptides play between the world of biopolymers and the world of organic synthetic chemistry. Not only were the meth
Stereoselectlve and regloselectlve cycloaddltlons to the choral cyclopentadlene z are reported. Dlastereoselectlve transformations of the adducts followed by a thermal retroreactlon yields pure enantlomers. CambrIdge CH2 LEW, U.K. Thanks are due t II Dr. r. tiofer b: for a sprlrs of shift-mear;ureln